在线精品国产_亚洲一级片在线免费观看_91久久久久久久久久久久久久_久久国产精品视频_久久久国产电影_久在线视频

歡迎進(jìn)入上海起發(fā)實(shí)驗(yàn)試劑有限公司!
產(chǎn)品展示
首頁(yè) > 產(chǎn)品展示 > > 分子生物學(xué)試劑 > integralmolecular中國(guó)代理

integralmolecular中國(guó)代理

描述:Integral Molecular offers biochemically modified Lipoparticles containing biotin tags and fluorophores to enable membrane proteins to be captured onto .

更新時(shí)間:2016-10-18
訪問(wèn)次數(shù):2080
廠商性質(zhì):代理商
詳情介紹

 LIPOPARTICLE TECHNOLOGY

Application Notes

THE LIPOPARTICLE
Lipoparticles incorporate high concentrations of properly folded and oriented membrane proteins on their surface. GPCRs, ion channels, and other complex membrane proteins can be incorporated into Lipoparticles at concentrations of 50-200 pmol/mg, 10-100 fold greater than cells or membrane preparations. Because Lipoparticles are virus-like particles (VLPs) based on the natural retroviral budding process, they are uniform in diameter (~150 nm) and maintain the orientation of incorporated membrane proteins. Integral Molecular produces, purifies, and delivers custom Lipoparticles containing user specified membrane proteins for applications in antibody development and drug discovery.

 

 


MODIFIED LIPOPARTICLES
Integral Molecular offers biochemically modified Lipoparticles containing biotin tags and fluorophores to enable membrane proteins to be captured onto solid supports and visualized without disrupting the conformation of incorporated receptor targets. Modified Lipoparticles are suited for use in specialized antibody development applications including:

 


ADVANTAGES
Lipoparticles offer distinct advantages over traditional sources of membrane proteins such as whole cells or membrane preparations:

Incorporation of difficult membrane proteins 
Lipoparticles can incorporate oligomeric and multispanning membrane proteins in their correct topology. Receptors that are toxic or poorly trafficked can also be incorporated into Lipoparticles. 

High purity and high concentrations of membrane proteins
Lipoparticles provide a source of concentrated membrane proteins that are free of cytoplasmic proteins and misoriented proteins, improving assay sensitivity and the specificity of immune responses. 

Convenient and consistent source of membrane proteins
Lipoparticles maintain membrane proteins in their native lipid environment, preserving protein conformation. Lipoparticles are shipped ready to use and are stable for months with refrigeration, thereby eliminating end-user preparation steps and reducing experimental variability. 
 

 


LIPOPARTICLE STRUCTURE
The Lipoparticle structure is based on membrane-enveloped retroviruses. Non-infectious, retroviral virus-like particles (VLPs) are produced when the viral protein 'Gag' buds through the host cell membrane. The Gag protein forms a core which becomes enwrapped by the cell membrane. Once the membrane ‘pinches’ off, newly formed Lipoparticles diffuse away from the cell, carrying target membrane proteins with it. Since the lipid membrane surrounding the Lipoparticle is derived directly from the host cell membrane, the incorporated receptors remain correctly oriented in a native lipid environment. Lipoparticles contain no viral genome or Envelope protein, and are replication incompetent and non-infectious, rendering them safe to manipulate in a standard laboratory environment.


LIPOPARTICLE QUALITY CONTROL
At Integral Molecular, Lipoparticles undergo rigorous quality control before they are shipped. As a result, the Lipoparticles you receive are highly purified, homogeneous, and stable for nths to years. Maintaining

 

  • Immunization
  • Phage and yeast display
  • Screening for and characterizing MAbs
  • Ligand binding assays
  • Probing cells and microarrays
  • Biosensor binding kinetics

 

 

 

Application versatility
Lipoparticles can be used with conventional formats such as microplates and beads, but their small size, exceptional purity, and stability also make them amenable to formats that are otherwise difficult for membrane proteins, such as microfluidics, microarrays, and biosensors. 

留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說(shuō)明:

  • 驗(yàn)證碼:

    請(qǐng)輸入計(jì)算結(jié)果(填寫(xiě)阿拉伯?dāng)?shù)字),如:三加四=7
主站蜘蛛池模板: 天天操天天爽天天射 | 亚洲精品高清在线观看 | 青青草国产免费久久久91 | 欧美亚洲图区 | 日本高清一区二区三区水蜜桃 | 日日做夜夜爽夜夜爽 | 天堂中文在线免费观看 | 亚洲 欧美 中文 日韩专区 | 色吊丝国产永久免费网址 | 午夜a今 | 日日摸夜夜 | 亚洲乱码在线视频 | 日韩a无v码在线播放免费 | 亚洲一区二区在线 | 日日摸日日碰夜夜爽97纠 | 日韩a| 在线观看国产黄色 | 日韩在线aⅴ免费视频 | 亚洲人成在线播放网站 | 一级成人a免费视频 | 午夜影院免费观看视频 | 五月婷婷在线观看视频 | 手机看片自拍日韩日韩高清 | 亚洲光棍天堂 | 亚洲高清影院 | 亚洲视频欧美视频 | 亚洲精品视频在线观看免费 | 天堂最新版资源www在线 | 亚洲男人在线 | 中文字幕欧美在线观看 | 亚洲产国偷v产偷v自拍色戒 | 射久久久| 青青草视频在线免费观看 | 日韩在线网 | 天堂网在线最新版www | 一区二区三区网站在线免费线观看 | 啪啪网视频 | 欧美亚洲综合视频 | 视频一区在线观看 | 日韩在线视频线视频免费网站 | 日韩成人免费在线视频 |